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CASE REPORT
Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 138-141

Primary systemic amyloidosis


Department of Dermatology, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinoutpalli, Krishna, Andhra Pradesh, India

Correspondence Address:
Haritha Samanthula
Department of Dermatology, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinnavutapalli, Vijayawada, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-8632.112352

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A 54-year-old male presented with nodular lesions over the tongue and progressive discoloration around the eyes of 1-year duration. Patient had history of dysphagia, dyspnea, dysphonia, progressive weakness, and tingling and numbness of the extremities. Clinical examination revealed macroglossia, periorbital purpura, carpal tunnel syndrome, and waxy nodules around the eyes and lateral borders of the tongue. A diagnosis of primary systemic amyloidosis was made. Biopsy showed eosinophilic deposits in the papillary dermis on hematoxylin and eosin (H and E) staining. Congo red stained sections showed areas of apple green birefringence under polarized light microscopy, confirming the diagnosis of amyloidosis.


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