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REVIEW ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 3  |  Page : 157-161

The molecular and genetic aspects in the pathogenesis and treatment of ameloblastoma


1 Department of Oral Pathology, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India
2 Department of Oral Pathology, Tagore Dental College, Chennai, Tamil Nadu, India
3 Department of Orthodontics, Tagore Dental College, Chennai, Tamil Nadu, India

Correspondence Address:
Nadeem Jeddy
Department of Oral Pathology, Thai Moogambigai Dental College and Hospital Golden George Nagar, Mogappair Chennai - 600 107, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-8632.117179

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Ameloblastomas are usually benign, locally aggressive neoplasms derived from the epithelial odontogenic tissues. The tumors are known for their propensity for local recurrence. Different mechanisms have been proposed to explain the mechanism behind the pathogenesis of ameloblastoma. The proper understanding of the pathogenetic mechanism involved in ameloblastoma and its proliferation, aids in constituting proper treatment. Molecules involved in the pathogenesis can serve as markers in long term follow-up. Expression of the ameloblastin and amelogenin genes in these tumors play a role and they potentiate their action through different mechanisms. This review focuses on the molecular changes that occur in ameloblastoma which has a bearing upon its treatment and prognosis.


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