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ORIGINAL ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 3  |  Page : 181-185

Antimicrobial resistance and metallo β lactamase in gram-negative isolates of hospital-acquired burn wound infections


Department of Microbiology, Prathima Institute of Sciences, Karimnagar, Andhra Pradesh, India

Correspondence Address:
Sanjeev D Rao
Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar - 505 001, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-8632.117184

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Introduction: In India, accidental contact with direct flame is the most common cause of burns. More than 90% of burn wounds are II and III degree, though surface area involved is less than 40%. Burn patients are at high risk of infection as a result of the nature of injury, immunocompromising effect of burn, prolonged hospital stay, and invasive procedures. Multidrug-resistant bacterial infection is major cause of mortality in these patients. Aim: This study was undertaken to determine the prevalence of metallo b lactamase (MBL) producing gram-negative isolates in burn wound infections, so as to guide the clinicians to select appropriate antimicrobial therapy and prevent the spread of MBL in gram-negative bacteria. Materials and Methods: Pus sample collected from 147 patients admitted to the burn unit, of government general hospital Karimnagar were processed by standard bacteriological methods. Imipenem-resistant isolates were screened for MBL production by combined disk test. Results: Study revealed that 40% Proteus and 19.05% Pseudomonas produce MBL and MBL producers are 100% resistant to imipenem and ceftazidime. Conclusion: Patients of burn with MBL-positive P. aeruginosa infections will have higher morbidity and mortality. Piperacillin/tazobactam seems to be effective options for the treatment of MBL-positive P. aeruginosa infections.


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