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CASE REPORT
Year : 2013  |  Volume : 2  |  Issue : 4  |  Page : 278-281

Acute megakaryocytic leukemia in a newborn with down syndrome


Department of Pediatrics, Gajraraja Medical College and Kamlaraja Hospital, Gwalior, Madhya Pradesh, India

Correspondence Address:
Ravi Ambey
Department of Pediatrics, Gajraraja Medical College and Kamlaraja Hospital, Gwalior, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-8632.122169

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Patient with Down's syndrome (DS) are found to have an increased risk of developing various hematological disorders. There is 46- to 83-fold increased risk of acute myeloid leukemia (AML) and 10- to 27-fold increased risk of acute lymphoid leukemia (ALL). One of the most characteristics feature of Down syndrome associated AML (DS-AML) is that vast majority of case (c.70%) of AML in DS are megakaryoblastic i.e. M7 as per FAB classification (DS- AMKL). Virtually, all cases of DS-AMKL occur within the first 5 years of life. The median age of presentation of AMKL is 1.8 years. We report a case of AMKL in a newborn with Down's syndrome.


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