|LETTER TO THE EDITOR
|Year : 2017 | Volume
| Issue : 4 | Page : 272
Patients with coronary slow-flow are more likely to be young men and active smokers
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
|Date of Web Publication||26-Dec-2017|
Dr. Yousef Rasmi
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Rasmi Y. Patients with coronary slow-flow are more likely to be young men and active smokers. J NTR Univ Health Sci 2017;6:272
We read the article “role of endothelial function in coronary slow-flow phenomenon with angiographically normal coronaries” written by Nathani  with a great interest. The author aimed to assess clinical, biochemical, electrocardiographic, and echocardiographic parameters in patients with a history of angina and whose coronary angiogram revealed normal epicardial coronaries with slow-flow with Coronary slow-flow phenomenon (CSFP). Matched patients with normal epicardial coronaries with normal flow were taken as controls. Moreover, patients with slow-flow in all the coronary arteries were included.
Thanks to the author for his contribution of the present study and for the successfully designed and presented study. We believe that these findings will enlighten further studies regarding the relation between CSX and endothelial dysfunction.
Coronary slow flow (CSF) is characterized by delayed opacification of epicardial arteries in the absence of occlusive disease. The pathophysiological mechanisms of SCF remain unclear. One of the possible mechanisms that may participate in the pathology of SCF is endothelial dysfunction related to the inflammatory process. It is shown that expression of inflammatory cytokines such as interferon gamma may influence the function of microvasculature and thereby contribute to the pathophysiology of SCF.,
We would like to make a minor criticism about the methodological aspects. Previous reports showed that patients with CSF were more likely to be young men and active smokers or with a history of smoking., However, in the study by Nathani, the mean age of CSF patients and controls were 54.36 ± 9.055 and 52.88 ± 9.177 years, respectively. Further, the study did not show meaningful association between heavy smokers with CSF compared to controls. It would be better if the authors explained these issues.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Nathani S. Role of endothelial function in coronary slow-flow phenomenon with angiographically normal coronaries. J NTR Univ Health Sci 2016;5:1-6. [Full text]
Li JJ, Qin XW, Li ZC, Zeng HS, Gao Z, Xu B, et al
. Increased plasma C-reactive protein and interleukin-6 concentrations in patients with slow coronary flow. Clin Chim Acta 2007;385:43-7.
Faramarz-Gaznagh S, Rasmi Y, Khadem-Ansari MH, Seyed-Mohammadzad MH, Bagher M, Nemati M, et al
. Transcriptional Activity of Gene Encoding Subunits R1 and R2 of Interferon Gamma Receptor in Peripheral Blood Mononuclear Cells in Patients with Slow Coronary Flow. J Med Biochem 2016;35:144-9.
Celebi H, Catakoglu AB, Kurtoglu H, Sener M, Hanavdelogullari R, Demiroglu C, et al
. The relation between coronary flow rate, plasma endothelin-1 concentrations, and clinical characteristics in patients with normal coronary arteries. Cardiovasc Revasc Med 2008;9:144-8.
Beltrame JF, Limaye SB, Horowitz JD. The coronary slow flow phenomenon-a new coronary microvascular disorder. Cardiology 2002;97:197-202.