Journal of Dr. NTR University of Health Sciences

CASE REPORT
Year
: 2013  |  Volume : 2  |  Issue : 4  |  Page : 278--281

Acute megakaryocytic leukemia in a newborn with down syndrome


Ravi Ambey, Ajay Gaur, Neha Agarwal 
 Department of Pediatrics, Gajraraja Medical College and Kamlaraja Hospital, Gwalior, Madhya Pradesh, India

Correspondence Address:
Ravi Ambey
Department of Pediatrics, Gajraraja Medical College and Kamlaraja Hospital, Gwalior, Madhya Pradesh
India

Patient with Down«SQ»s syndrome (DS) are found to have an increased risk of developing various hematological disorders. There is 46- to 83-fold increased risk of acute myeloid leukemia (AML) and 10- to 27-fold increased risk of acute lymphoid leukemia (ALL). One of the most characteristics feature of Down syndrome associated AML (DS-AML) is that vast majority of case (c.70%) of AML in DS are megakaryoblastic i.e. M7 as per FAB classification (DS- AMKL). Virtually, all cases of DS-AMKL occur within the first 5 years of life. The median age of presentation of AMKL is 1.8 years. We report a case of AMKL in a newborn with Down«SQ»s syndrome.


How to cite this article:
Ambey R, Gaur A, Agarwal N. Acute megakaryocytic leukemia in a newborn with down syndrome.J NTR Univ Health Sci 2013;2:278-281


How to cite this URL:
Ambey R, Gaur A, Agarwal N. Acute megakaryocytic leukemia in a newborn with down syndrome. J NTR Univ Health Sci [serial online] 2013 [cited 2020 May 25 ];2:278-281
Available from: http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2013;volume=2;issue=4;spage=278;epage=281;aulast=Ambey;type=0