Year : 2020 | Volume
: 9 | Issue : 1 | Page : 25--31
The cytomorphological spectrum of Hashimoto thyroiditis and its correlation with serological parameters: A study in the coastal region
Nibedita Sahoo1, Sujata Naik1, Pranita Mohanty1, Pradeep N Sahoo2, Prateek Das1
1 Department of Pathology, IMS and SUM Hospital, Bhubaneswar, Odisha, India
2 Department of Internal Medicine, AMRI Hospital, Bhubaneswar, Odisha, India
Objective: To analyse the detailed cytomorphological spectrum in Hashimoto thyroiditis (HT), cytological grading and its significance with the hormonal and antibody status
Methods: This is both a prospective and retrospective study of 102 cases of HT in a tertiary care institute of the eastern part of India. Detailed cytological parameters were observed, graded and correlated with the serological parameters.
Results: The majority of patients were females with a younger age group (21–30 years) and diffuse thyromegaly was the common presentation. A good number of cases showed neutrophilic infiltration, background colloid and follicular hyperplasia. Among the cytological parameters, Hurthle cell change was correlated with hypothyroidism (P < 0.05) but there was no significant correlation with the anti-TPO antibody. Statistical correlation of different cytological grades with the anti-TPO antibody was significant (P < 0.05), however the thyroid hormone profile with cytological grade and TPO level were not significant (P > 0.05).
Conclusion: A younger age of presentation in a coastal area with iodine sufficiency and supplementation needs further epidemiological studies. Fine-needle aspiration cytology is superior to other sophisticated methods in diagnosing HT, even in seronegative cases. A good number of cases displaying folliculolysis by neutrophils needs to be corroborated by larger studies. One should be vigilant while examining slides to rule out associated malignancy.
Dr. Nibedita Sahoo
Department of Pathology, IMS and SUM Hospital, Bhubaneswar, Odisha-19
|How to cite this article:|
Sahoo N, Naik S, Mohanty P, Sahoo PN, Das P. The cytomorphological spectrum of Hashimoto thyroiditis and its correlation with serological parameters: A study in the coastal region.J NTR Univ Health Sci 2020;9:25-31
|How to cite this URL:|
Sahoo N, Naik S, Mohanty P, Sahoo PN, Das P. The cytomorphological spectrum of Hashimoto thyroiditis and its correlation with serological parameters: A study in the coastal region. J NTR Univ Health Sci [serial online] 2020 [cited 2020 Jun 1 ];9:25-31
Available from: http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2020;volume=9;issue=1;spage=25;epage=31;aulast=Sahoo;type=0