| CASE REPORT |
|
| Year : 2013 | Volume
: 2
| Issue : 4 | Page : 278-281 |
|
|
Acute megakaryocytic leukemia in a newborn with down syndrome
Ravi Ambey, Ajay Gaur, Neha Agarwal
Department of Pediatrics, Gajraraja Medical College and Kamlaraja Hospital, Gwalior, Madhya Pradesh, India
Correspondence Address:
Ravi Ambey
Department of Pediatrics, Gajraraja Medical College and Kamlaraja Hospital, Gwalior, Madhya Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2277-8632.122169
|
|
|
Patient with Down's syndrome (DS) are found to have an increased risk of developing various hematological disorders. There is 46- to 83-fold increased risk of acute myeloid leukemia (AML) and 10- to 27-fold increased risk of acute lymphoid leukemia (ALL). One of the most characteristics feature of Down syndrome associated AML (DS-AML) is that vast majority of case (c.70%) of AML in DS are megakaryoblastic i.e. M7 as per FAB classification (DS- AMKL). Virtually, all cases of DS-AMKL occur within the first 5 years of life. The median age of presentation of AMKL is 1.8 years. We report a case of AMKL in a newborn with Down's syndrome. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
