| REVIEW ARTICLE |
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| Year : 2015 | Volume
: 4
| Issue : 3 | Page : 141-144 |
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Oral field cancerization: An update of evidences
Balkuntla Krishnamurthy Ashwini, Prakash Sharada, Kyadala Nagaraja Hema, Srinivas Murthy Chitra
Department of Oral and Maxillofacial Pathology, AECS Maaruti College of Dental Sciences and Research Centre, Kammanahalli, Bengaluru, Karnataka, India
Correspondence Address:
Balkuntla Krishnamurthy Ashwini
Department of Oral and Maxillofacial Pathology, AECS Maaruti College of Dental Sciences and Research Centre, #108, Hulimavu Tank Bund Road, B. T. M. 6th Stage, 1st Phase, Kammanahalli, Off. Bannerghatta Road, Bengaluru - 560 076, Karnataka
India
 Source of Support: Nil., Conflict of Interest: None declared.  | Check |
DOI: 10.4103/2277-8632.165403
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Patients with head and neck squamous cell carcinoma often develop multiple premalignant lesions; this led to the concept of field-effect in cancer which was originated by Slaughter et al. in the year 1953. Though this was based on histopathological observations, the development of modern molecular technologies has extended the field effect concept by exploring the molecular abnormalities in tissues that appear histologically normal. In this update, we discuss in detail about the origin, principle, various theories used to explain this effect, molecular findings and therapeutic implications related to oral field cancerization. |
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