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Year : 2016  |  Volume : 5  |  Issue : 2  |  Page : 163-164

Gamna-Gandy bodies in adenomatous goiter: A morphological curiosity

1 Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India
2 Department of Surgical Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Date of Web Publication5-Jul-2016

Correspondence Address:
Amitabh Jena
Department of Surgical Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati - 517 507, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2277-8632.185458

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How to cite this article:
Patnayak R, Jena A, Maduri A, Reddy NR. Gamna-Gandy bodies in adenomatous goiter: A morphological curiosity. J NTR Univ Health Sci 2016;5:163-4

How to cite this URL:
Patnayak R, Jena A, Maduri A, Reddy NR. Gamna-Gandy bodies in adenomatous goiter: A morphological curiosity. J NTR Univ Health Sci [serial online] 2016 [cited 2022 Jan 19];5:163-4. Available from: https://www.jdrntruhs.org/text.asp?2016/5/2/163/185458


Gamna-Gandy (G-G) bodies are sclerosiderotic foci, commonly found in spleen. They are also known as siderotic nodules or tobacco flecks. [1] They are defined as spheroidal yellow-brown foci of dense fibrous tissue and collagenous fibers composed of calcium and hemosiderin pigments. These siderotic nodules were noticed since early 20th century. They were first seen in the spleen. The earlier erroneous notion was it may be due to fungal infection because of the presence of unusual "bamboo-like and articulated" fibers in these lesions often mimicking fungal hyphae. They occur because of the organization of small hemorrhages with accumulation of hemosiderin. Apart from spleen, G-G bodies are described in atrial myxomas. Rarely they have been reported in other organs like lymph nodes, thymoma, follicular adenoma of thyroid, colorectal polyp, renal cell carcinoma, and central and peripheral nervous system neoplasms. [2],[3],[4],[5]

Recently, we encountered G-G bodies in a case of adenomatous goiter of thyroid. This patient was a 64-year-old male who had a huge swelling of the thyroid, measuring 25 cm Χ 15 cm, present since the last 20 years. He underwent fine needle aspiration cytology (FNAC), where it was reported as adenomatous goiter. Subsequently, the patient underwent total thyroidectomy that revealed features of adenomatous goiter. One focus showed presence of typical G-G bodies [Figure 1],[Figure 2] and [Figure 3]. Perls' stain was done and it showed positive [Figure 4]. This patient has undergone FNAC that might have resulted in hemorrhage, subsequently, leading to the formation of G-G bodies. Though FNAC is a routine procedure in thyroid lesions, G-G bodies are not routinely reported. So the pathogenesis of G-G bodies remains an enigma.
Figure 1: Gamna-Gandy body and adjacent thyroid parenchyma (Hematoxylin and eosin 40x)

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Figure 2: Gamna-Gandy body adjacent thyroid follicles and hemosiderin laden macrophages (Hematoxylin and eosin 100x)

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Figure 3: Gamna-Gandy body showing fungal hyphae like structure (Hematoxylin and eosin 200x)

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Figure 4: Perls' stain showing positivity of Gamna-Gandy body (Perls' stain 200x)

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  References Top

Shah OJ, Shah P, Robbani I, Mir F, Nazir P. An 18-year-old female with recurrent esophageal variceal bleeding. Ann Saudi Med 2009;29:61.  Back to cited text no. 1
Bhatnagar G, George E, Al Lawati F. Cardiac myxomas with Gamna Gandy bodies - A case report and review of literature. Gulf J Oncolog 2009;64-7.  Back to cited text no. 2
Kleinschmidt-DeMasters BK. Gamna-Gandy bodies in surgical neuropathology specimens: Observations and a historical note. J Neuropathol Exp Neurol 2004;63:106-12.  Back to cited text no. 3
Leroy X, Aubert S, Gosselin B. Gamna-Gandy nodules in a renal clear cell carcinoma. Arch Pathol Lab Med 2003;127:372.  Back to cited text no. 4
Jiménez-Heffernan JA, Tejerina E, de la Morena E, Sanz Ortega E. Gamna-Gandy bodies in an adenomatous colorectal polyp. Indian J Pathol Microbiol 2010;53:876-7.  Back to cited text no. 5


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]

This article has been cited by
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[Pubmed] | [DOI]


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