Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Print this page Email this page Users Online: 148
Year : 2016  |  Volume : 5  |  Issue : 4  |  Page : 286-290

Low serum 1,25(OH) 2 D levels: A risk factor for periodontitis

Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India

Correspondence Address:
Rajashree Dasari
Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Road No. 5, Kamala Nagar, Dilsukhnagar, Hyderabad - 500 060, Telangana
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2277-8632.196589

Rights and Permissions

Context: Vitamin D has been associated with bone health and it is well understood that vitamin D deficiency leads to various disorders. 1,25(OH) 2 D maintains oral health through its effect on bone and mineral metabolism and innate immunity. Aims: The aim was to evaluate the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and 1,25(OH) 2 D and periodontal disease risk and also the effect of low serum levels on periodontal surgical outcomes in periodontitis patients. Settings and Design: The study was designed as a case control clinical trial that was conducted to identify the risk of low levels of serum vitamin D in progression of the disease and also in periodontal healing process. Materials and Methods: A total of 51 chronic periodontitis patients and 33 periodontally healthy subjects were included in the study. The serum levels of both 25(OH)D and 1,25(OH) 2 D were determined. Parameters, such as plaque index, bleeding on probing (BOP), clinical attachment level (CAL), and pocket depth (PD), were measured at baseline, 6 weeks, and 6 months to assess the periodontal status. Statistical Analysis Used: The data were analyzed using chi-square test, independent sample t-test, repeated measures analysis of variance (ANOVA) with post hoc Bonferroni test. Results: There was statistically significant association between serum 1,25(OH) 2 D level and periodontal health status (12.73 ± 4.19 vs. 20.36 ± 5.50). The subjects with chronic periodontitis showed low serum levels of 1,25(OH) 2 D, and individuals with severe deficiency have shown less clinical attachment gain and PD reduction when compared with minimal deficiency patients after the surgery. Conclusions: Analysis of these data suggest that low serum 1,25(OH) 2 D level seem to be associated with chronic periodontitis and 1,25(OH)2D deficiency negatively affects the periodontal surgical treatment outcome.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded236    
    Comments [Add]    

Recommend this journal