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Year : 2017  |  Volume : 6  |  Issue : 3  |  Page : 158-162

The assessment of systemic inflammatory response in apparently healthy adult smokers in Nnewi, South East Nigeria

1 Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra, Nigeria
2 Department of Haematology, Faculty of Medicine, College of Health Sciences Nnamdi Azikiwe University, Nnewi, Anambra, Nigeria

Correspondence Address:
John C Aneke
Department of Haematology, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, PMB 5001, Nnewi, Anambra
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Source of Support: None, Conflict of Interest: None


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Background: Induction of systemic inflammation is thought to underlie major organ dysfunction in cigarette smokers. Objective: The objective of the study is to estimate the levels of inflammatory markers (the leukocyte count and C-reactive protein [CRP]) in adult smokers in Nnewi metropolis, South East Nigeria. Subjects and Methods: A total of 120 adults, comprising of 60 smokers and age-matched nonsmokers, respectively were recruited. Five millilitre of venous blood was collected from each participant, of which 2 ml was used for full blood count estimation, using the Sysmex NX® hematology analyzer, while 3 ml was dispensed into plain tube and serum was extracted for CRP measurement, using the ELISA technique. Statistical analysis was done using SPSS (version 20), the students t-test was used for the comparison of means, and level of statistical significance set at (P < 0.05). Results: The serum CRP level was significantly higher in smokers compared with controls (P < 0.001) and the neutrophil count, neutrophil/lymphocyte ratio (NLR), and CRP were significantly higher in study individuals with smoking history of >5 years, compared with those whose smoking history was <5 years (P = 0.001, 0.001, and <0.001, respectively). The white cell count, eosinophil count, and serum CRP levels were significantly higher in individuals who smoked >5 sticks of cigarettes in 1 month (P = 0.023, 0.004, and <0.001, respectively). Conclusion: Cigarette smoking is associated with a significant acute inflammatory response which becomes exaggerated with increasing duration and frequency of exposure.

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