Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Print this page Email this page Users Online: 203
REVIEW ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 4  |  Page : 209-212

Association of chronic periodontitis and oral cancer: A review on pathogenetic mechanism and clinical implication


1 Departments of Oral Pathology and Microbiology, Azeezia College of Dental Science and Research, Meeyannoor P O, Kollam, Kerala, India
2 Departments of Periodontology andImplantology, Azeezia College of Dental Science and Research, Meeyannoor P O, Kollam, Kerala, India

Correspondence Address:
Dr. R J Krishnasree
Department of Oral Pathology and Microbiology, Azeezia College of Dental Science and Research, Meeyannoor P O, Kollam, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JDRNTRUHS.JDRNTRUHS_84_20

Rights and Permissions

The objective of this article is to review the available literature on the pathogenetic mechanisms involved in the association between oral cancer and periodontitis and its clinical implications. Periodontal diseases are characterized by chronic inflammation as a response to the host tissue invasion by multi-species microbial community. The activation of different inflammatory cascades by chronic periodontitis negatively affects the oral mucosa and has the potential to activate carcinogenesis. An electronic literature search was conducted in the MEDLINE and EMBASE databases. The search terms used were “CHRONIC PERIODONTITIS, ORAL CANCER, and PATHOGENESIS”. Original articles published between January 1990 and March 2018 was identified. Thirty-two potentially relevant articles were selected and included in the review after assessing the title and abstract. Several studies have shown that the inflammatory mediators produced in periodontal diseases may lead to angiogenesis and subsequently promote tumorogenesis. Periodontitis being a polymicrobial disease promotes carcinogenesis by evoking various inflammatory pathways. The rationale behind the association of oral cancer and periodontitis is that inflammation plays a key role in the pathogenesis of both conditions.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed492    
    Printed50    
    Emailed0    
    PDF Downloaded71    
    Comments [Add]    

Recommend this journal