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CASE REPORT
Year : 2021  |  Volume : 10  |  Issue : 4  |  Page : 282-285

Acrania-exencephaly-anencephaly sequence


1 Department of Pathology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India
2 Department of Physiology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India

Correspondence Address:
Dr. Sunil Vitthalrao Jagtap
Department of Pathology, Krishna Institute of Medical Sciences, Deemed University, Karad, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdrntruhs.jdrntruhs_89_21

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Acrania–exencephaly–anencephaly sequence is rare forms of neural tube defects. The progression is from a relatively normal-appearing exposed brain due to an absent cranium called as acrania, to an amorphous brain mass term as exencephaly. We present a case of 20 years female, nonconsaguinous marriage, G1P0A0 having amenorrhea since 3 months. On ultrasonography, a single fetus of gestational age of about 15 weeks gestation showed congenital malformation- acrania with exencephaly. Final impression on fetal autopsy given was acrania–exencephaly with deformed brain, ill-formed cervical C1, 2 spine, bilateral pulmonary immaturity- Grade II with pulmonary congestion and hemorrhage. We are presenting this rare fetal anomaly of acrania–exencephaly–anenecephaly sequence for its clinical, radio imaging, and fetal autopsy findings.


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